Searchable abstracts of presentations at key conferences in endocrinology

ea0029p803 | Endocrine tumours and neoplasia | ICEECE2012

Estradiol Potentiates the Inhibitory Effects of SOM230 on Prostate Cells in vitro Up-regulating Ligand Binding Domain Expression of SSTR2 and 5

Rossi V. , Visconti D. , Bellastella G. , Palumbo V. , Abbondanza C. , De Rosa C. , Bellastella A. , Sinisi A.

The effects in vitro and in vivo of somatostatin (SS) analogues are linked to the presence of specific binding sites on target cells. Estradiol (E2) may modulate the expression of SS receptors (SSTR) in some cell models, including breast cancer and pituitary cells. Aim of this study was to evaluate the effects of E2 on SSTR1-5 ligand binding domains (LBD) expression levels in prostate epithelial cells (PEC).Methods: We investigated the effe...